Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 7/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9528605 | 0.99 | OPRD1 (1.00) | OPRD1OPRK1NPC1 | |
| SCHEMBL9528532 | 0.99 | OPRD1 (0.98) | OPRD1OPRK1NPC1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9529525 | 0.98 | OPRD1 (0.98) | OPRD1OPRK1 | |
| Maleic Acid SCHEMBL7642825 | 0.94 | OPRD1 (0.89) | OPRD1OPRK1NPC1 | |
| Fumaric Acid SCHEMBL7642838 | 0.94 | OPRD1 (0.89) | OPRD1OPRK1NPC1 | |
| SCHEMBL9529598 | 0.93 | OPRD1 (0.87) | OPRD1OPRK1NPC1CYP1A2CYP3A4 | |
| SCHEMBL9530422 | 0.92 | OPRD1 (0.85) | OPRD1OPRK1NPC1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9528583 | 0.92 | OPRD1 (0.87) | OPRD1OPRK1NPC1 | |
| Hydrochloric Acid SCHEMBL9532344 | 0.91 | OPRD1 (0.85) | OPRD1OPRK1NPC1CYP1A2CYP3A4 | |
| SCHEMBL9528203 | 0.90 | OPRD1 (0.82) | OPRD1OPRK1NPC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | claimed |
| EP-0372694-A2 | Azacyclic derivatives with diuretic activity | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1990-06-13 | — | — | EP | claimed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | claimed |
| JP-1301662-A | — | — | None | — | — | JP | disclosed |
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-5087630-A | Diuretics | DR. LO. ZAMBELETTI SPA (IT) | 1992-02-11 | — | — | US | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| JP-H01301662-A | TETRAHYDROISOQUINOLINE DERIVATIVE | GLAXO GROUP LTD | 1989-12-05 | — | — | JP | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |
| EP-0330469-A2 | Tetrahydroisoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |