Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | MITF | O75030 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529442 | 0.82 | HTT (0.40) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL9234085 | 0.78 | BPTF (0.48) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL9531592 | 0.75 | HTT (0.44) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451726 | 0.72 | ALDH1A1 (0.45) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451356 | 0.72 | ALDH1A1 (0.45) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451369 | 0.71 | ALDH1A1 (0.44) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451526 | 0.71 | ALDH1A1 (0.44) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL14501195 | 0.71 | HTT (0.44) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451492 | 0.71 | ALDH1A1 (0.44) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL29451777 | 0.71 | ALDH1A1 (0.45) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |