Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.66 |
| ▸ | LMNA | P02545 | 7/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18695079 | 1.00 | EPHX1 (0.69) | EPHX1SMN1; SMN2LMNANPSR1ALOX12 | |
| SCHEMBL10531842 | 1.00 | EPHX1 (0.69) | EPHX1SMN1; SMN2LMNANPSR1ALOX12 | |
| SCHEMBL28756963 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNANPSR1ALOX12RAB9A | |
| SCHEMBL9530001 | 0.84 | EPHX1 (0.50) | EPHX1SMN1; SMN2LMNANPSR1ALOX12 | |
| SCHEMBL9755532 | 0.82 | EPHX1 (1.00) | EPHX1SMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL18737536 | 0.82 | EPHX1 (0.69) | EPHX1SMN1; SMN2LMNANPSR1RAB9A | |
| SCHEMBL14506148 | 0.82 | EPHX1 (1.00) | EPHX1SMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL2752610 | 0.80 | EPHX1 (0.97) | EPHX1SMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL11697622 | 0.80 | NPSR1 (1.00) | EPHX1SMN1; SMN2LMNANPSR1ALOX12 | |
| SCHEMBL11149053 | 0.80 | SMN1; SMN2 (0.97) | EPHX1SMN1; SMN2LMNANPSR1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118791405-A | Synthesis method of (E) - (N' - (4-cyanophenyl) -N-cyclooctylcarbamoylamino) -2-glycine | 郑州大学 | 2024-10-18 | — | — | CN | claimed |
| CN-106456592-B | Sweet receptor antagonist | 味之素株式会社 | 2019-06-18 | — | — | CN | claimed |
| US-9907766-B2 | Sweetness receptor antagonist | AJINOMOTO CO., INC. (JP) | 2018-03-06 | — | — | US | claimed |
| EP-3162366-A1 | SWEETNESS RECEPTOR ANTAGONIST | Ajinomoto Co., Inc. (JP) | 2017-05-03 | — | — | EP | claimed |
| US-20170101372-A1 | SWEETNESS RECEPTOR ANTAGONIST | AJINOMOTO CO., INC. (JP) | 2017-04-13 | — | — | US | claimed |
| CN-106456592-A | Sweetness receptor antagonist | 味之素株式会社 | 2017-02-22 | — | — | CN | claimed |
| CN-118791405-A | Synthesis method of (E) - (N' - (4-cyanophenyl) -N-cyclooctylcarbamoylamino) -2-glycine | 郑州大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-118791405-A | Synthesis method of (E) - (N' - (4-cyanophenyl) -N-cyclooctylcarbamoylamino) -2-glycine | 郑州大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-106456592-B | Sweet receptor antagonist | 味之素株式会社 | 2019-06-18 | — | — | CN | disclosed |
| US-9907766-B2 | Sweetness receptor antagonist | AJINOMOTO CO., INC. (JP) | 2018-03-06 | — | — | US | disclosed |
| US-9907766-B2 | Sweetness receptor antagonist | AJINOMOTO CO., INC. (JP) | 2018-03-06 | — | — | US | disclosed |
| US-9907766-B2 | Sweetness receptor antagonist | AJINOMOTO CO., INC. (JP) | 2018-03-06 | — | — | US | disclosed |
| EP-3162366-A1 | SWEETNESS RECEPTOR ANTAGONIST | Ajinomoto Co., Inc. (JP) | 2017-05-03 | — | — | EP | disclosed |
| US-20170101372-A1 | SWEETNESS RECEPTOR ANTAGONIST | AJINOMOTO CO., INC. (JP) | 2017-04-13 | — | — | US | disclosed |
| US-20170101372-A1 | SWEETNESS RECEPTOR ANTAGONIST | AJINOMOTO CO., INC. (JP) | 2017-04-13 | — | — | US | disclosed |
| US-20170101372-A1 | SWEETNESS RECEPTOR ANTAGONIST | AJINOMOTO CO., INC. (JP) | 2017-04-13 | — | — | US | disclosed |
| CN-106456592-A | Sweetness receptor antagonist | 味之素株式会社 | 2017-02-22 | — | — | CN | disclosed |
| EP-0299533-B1 | HIGH POTENCY SWEETENING AGENTS | THE NUTRASWEET COMPANY (a Delaware corporation) (US) | 1993-04-07 | — | — | EP | disclosed |
| WO-1989000563-A1 | HIGH POTENCY SWEETENING AGENTS | THE NUTRASWEET COMPANY (US) | 1989-01-26 | — | — | WO | disclosed |
| EP-0299533-A2 | High potency sweetening agents | THE NUTRASWEET COMPANY (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101372-A1 | SWEETNESS RECEPTOR ANTAGONIST | GPR119, GLP1R, SUCNR1 | EPHX1 4300/4885SMN1; SMN2 3734/4885LMNA 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.