Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | BRS3 | P32247 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6008001 | 0.90 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9529590 | 0.84 | FOLH1 (0.41) | FOLH1LTB4RLTB4R2HDAC1HDAC6 | |
| SCHEMBL6005968 | 0.78 | AGTR1 (0.44) | AGTR1AGTR2BRS3 | |
| SCHEMBL6007271 | 0.76 | AGTR1 (0.46) | AGTR1AGTR2BRS3 | |
| SCHEMBL6006118 | 0.75 | BRS3 (0.46) | AGTR1AGTR2BRS3 | |
| SCHEMBL6004609 | 0.74 | AGTR1 (0.45) | AGTR1AGTR2BRS3 | |
| SCHEMBL6007274 | 0.74 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL6006332 | 0.73 | BRS3 (0.43) | AGTR1AGTR2BRS3 | |
| SCHEMBL6007542 | 0.73 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL6005906 | 0.73 | BRS3 (0.49) | AGTR1AGTR2BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | disclosed |