SCHEMBL9529522

SCHEMBL9529522

C=C(c1ccccc1)C(O)(Cn1cncn1)c1ccc(F)cc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.56
KMT2A Q03164 1/20 0.54
CYP19A1 P11511 6/20 0.46
CYP3A4 P08684 4/20 0.46
CYP2C9 P11712 3/20 0.46
CYP2C19 P33261 3/20 0.46
LMNA P02545 2/20 0.46
CYP11B1 P15538 1/20 0.46
CYP11B2 P19099 1/20 0.46
ADRA1A P35348 1/20 0.46
CYP51A1 Q16850 1/20 0.46
MAPK1 P28482 2/20 0.36
CYP2B6 P20813 1/20 0.36
CYP3A5 P20815 1/20 0.36
CYP3A7 P24462 1/20 0.36
CYP3A43 Q9HB55 1/20 0.36
CYP46A1 Q9Y6A2 1/20 0.36
FDPS P14324 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9530582 0.94 KMT2A (0.57) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9530065 0.89 KMT2A (0.53) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9530860 0.88 HSP90AA1 (0.56) HSP90AA1KMT2ACYP19A1CYP3A4LMNA
SCHEMBL9530141 0.84 CYP3A4 (0.63) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9530580 0.83 CYP3A4 (0.50) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9533503 0.83 KMT2A (0.55) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL27336382 0.82 HSP90AA1 (0.83) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9530225 0.81 KMT2A (0.50) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9532348 0.81 CYP3A4 (0.56) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9
SCHEMBL9529524 0.79 CYP3A4 (0.66) HSP90AA1KMT2ACYP19A1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP claimed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US claimed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP claimed
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
EP-0390850-A4 ANTIFUNGAL CARBINOLS 1990-12-05 EP disclosed
US-4965280-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-23 US disclosed
US-4965281-A CONTROLLING PLANT AND MAMMAL FUNGAL INFECTIONS E. I. DU PONT DE NEMOURS AND CMOPANY (US) 1990-10-23 US disclosed
EP-0390850-A1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1990-10-10 EP disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005581-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
US-4734323-A POLYBUTADIENE TOYODA GOSEI CO., LTD. (JP) 1988-03-29 US disclosed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP disclosed