SCHEMBL9530860

SCHEMBL9530860

C=C(c1ccccc1)C(O)(Cn1cncn1)c1ccc(Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.56
KMT2A Q03164 3/20 0.54
ALDH1A1 P00352 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP19A1 P11511 5/20 0.41
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
HTT P42858 3/20 0.39
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.38
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9531219 0.90 KMT2A (0.51) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL9529522 0.88 HSP90AA1 (0.56) HSP90AA1KMT2ACYP3A4CYP19A1LMNA
SCHEMBL9735470 0.86 KMT2A (0.52) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL8675739 0.84 KMT2A (0.56) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL9530252 0.84 HSP90AA1 (0.45) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL9530158 0.81 KMT2A (0.50) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL9530582 0.81 KMT2A (0.57) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
Hydrochloric Acid SCHEMBL11139130 0.81 HSP90AA1 (0.81) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1
SCHEMBL29594737 0.80 KMT2A (0.46) HSP90AA1KMT2AALDH1A1CYP3A4PDCD1
SCHEMBL9530687 0.79 KMT2A (0.46) HSP90AA1KMT2AALDH1A1CYP3A4CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP claimed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US claimed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP claimed
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
EP-0390850-A4 ANTIFUNGAL CARBINOLS 1990-12-05 EP disclosed
US-4965281-A CONTROLLING PLANT AND MAMMAL FUNGAL INFECTIONS E. I. DU PONT DE NEMOURS AND CMOPANY (US) 1990-10-23 US disclosed
US-4965280-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-23 US disclosed
EP-0390850-A1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1990-10-10 EP disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005581-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP disclosed