Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393370 | 0.85 | AGTR1 (0.44) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9529645 | 0.83 | AGTR1 (0.41) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9846446 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9528977 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9528271 | 0.78 | AGTR1 (0.38) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL7400399 | 0.77 | AGTR1 (0.45) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9532148 | 0.77 | AGTR1 (0.46) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL7394885 | 0.76 | AGTR1 (0.44) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL9529656 | 0.76 | AGTR1 (0.43) | AGTR1AGTR2PPARGLTB4R2ABCC3 | |
| SCHEMBL7445559 | 0.75 | AGTR1 (0.46) | AGTR1AGTR2PPARGLTB4R2ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | disclosed |