SCHEMBL9530158

SCHEMBL9530158

C=C(c1ccc(Cl)cc1)C(O)(Cn1cncn1)c1ccccc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.50
CYP3A4 P08684 8/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP2C9 P11712 7/20 0.43
CYP2C19 P33261 7/20 0.43
LMNA P02545 3/20 0.43
CYP19A1 P11511 3/20 0.43
HSP90AA1 P07900 2/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
ADRA1A P35348 1/20 0.43
CYP51A1 Q16850 1/20 0.43
HTT P42858 3/20 0.38
MAPT P10636 1/20 0.38
CYP1A2 P05177 3/20 0.37
CYP2D6 P10635 3/20 0.37
KCNH2 Q12809 2/20 0.37
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9530580 0.91 CYP3A4 (0.50) KMT2ACYP3A4CYP2C9CYP2C19LMNA
SCHEMBL7260674 0.89 CYP19A1 (0.43) KMT2ACYP3A4CYP2C9CYP2C19LMNA
SCHEMBL9530104 0.87 CYP3A4 (0.61) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL9530225 0.84 KMT2A (0.50) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL8675739 0.82 KMT2A (0.56) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL9530687 0.82 KMT2A (0.46) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL9530860 0.81 HSP90AA1 (0.56) KMT2ACYP3A4ALDH1A1LMNACYP19A1
SCHEMBL7260497 0.80 HSP90AA1 (0.42) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL9530252 0.80 HSP90AA1 (0.45) KMT2ACYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL9530141 0.80 CYP3A4 (0.63) KMT2ACYP3A4CYP2C9CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP claimed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US claimed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP claimed
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
EP-0390850-A4 ANTIFUNGAL CARBINOLS 1990-12-05 EP disclosed
US-4965281-A CONTROLLING PLANT AND MAMMAL FUNGAL INFECTIONS E. I. DU PONT DE NEMOURS AND CMOPANY (US) 1990-10-23 US disclosed
US-4965280-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-23 US disclosed
EP-0390850-A1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1990-10-10 EP disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005581-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
EP-0251086-A2 Antifungal carbinols THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP disclosed