Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530175 | 1.00 | BCHE (0.42) | BCHEACHEALDH1A1MAPTTP53 | |
| SCHEMBL10546302 | 0.74 | MAPT (0.37) | ALDH1A1MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL10546311 | 0.74 | MAPT (0.37) | ALDH1A1MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL10546277 | 0.74 | MAPT (0.37) | ALDH1A1MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL10546288 | 0.74 | MAPT (0.37) | ALDH1A1MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL9534753 | 0.73 | SOAT1 (0.43) | ALDH1A1MAPTTP53HSP90AA1ALOX12 | |
| SCHEMBL9534744 | 0.73 | SOAT1 (0.43) | ALDH1A1MAPTTP53HSP90AA1ALOX12 | |
| SCHEMBL10672053 | 0.73 | SOAT1 (0.43) | ALDH1A1MAPTTP53HSP90AA1ALOX12 | |
| SCHEMBL10695299 | 0.69 | AVPR1A (0.42) | ALDH1A1MAPTTP53HSP90AA1ALOX12 | |
| SCHEMBL4175659 | 0.68 | BCHE (0.51) | BCHEACHEALDH1A1L3MBTL1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |