Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.54 |
| ▸ | PRCP | P42785 | 5/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453173 | 0.85 | OPRM1 (0.56) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL329925 | 0.84 | OPRM1 (0.57) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL329828 | 0.84 | OPRM1 (0.57) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL330238 | 0.84 | OPRM1 (0.57) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL1009943 | 0.76 | PRCP (0.64) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL5898800 | 0.76 | PRCP (0.61) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL10741159 | 0.76 | HTR2A (0.50) | — | |
| SCHEMBL4340396 | 0.76 | PRCP (0.61) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL14934071 | 0.76 | PRCP (0.50) | OPRM1PRCPSLC22A1GAASMN1; SMN2 | |
| SCHEMBL14934054 | 0.76 | PRCP (0.50) | OPRM1PRCPSLC22A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |