Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 4/20 | 0.43 |
| ▸ | ADH5 | P11766 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980582 | 0.88 | IDO1 (0.49) | IDO1TBXAS1MYCADH5CYP3A4 | |
| SCHEMBL726313 | 0.81 | IDO1 (0.59) | IDO1MYCADH5CYP3A4CYP1A2 | |
| SCHEMBL5690863 | 0.80 | MEN1 (0.50) | IDO1CD274ADH5CYP3A4CYP1A2 | |
| SCHEMBL27636993 | 0.78 | CYP3A4 (0.62) | IDO1TBXAS1ADH5CYP3A4MEN1 | |
| SCHEMBL5319528 | 0.78 | IDO1 (0.47) | IDO1TBXAS1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL9640288 | 0.77 | IDO1 (0.50) | IDO1TBXAS1ADH5CYP3A4CYP1A2 | |
| SCHEMBL9530614 | 0.77 | IDO1 (0.48) | IDO1ADH5CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7780279 | 0.76 | IDO1 (0.49) | IDO1TBXAS1ADH5CYP3A4CYP1A2 | |
| SCHEMBL16719674 | 0.76 | CYP3A4 (0.45) | IDO1TBXAS1ADH5CYP3A4CYP1A2 | |
| SCHEMBL4020894 | 0.75 | CYP3A4 (0.56) | IDO1CD274CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |