Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533881 | 0.90 | CHRM1 (0.55) | KDM4EAGTR1AGTR2CHRM1ALDH1A1 | |
| SCHEMBL9422759 | 0.88 | APEX1 (0.84) | APEX1KDM4EGLAAGTR1AGTR2 | |
| Bicarbonate SCHEMBL28244886 | 0.81 | POLB (0.68) | CHRM1ALDH1A1 | |
| Benzene SCHEMBL28277475 | 0.79 | POLB (0.77) | CHRM1ALDH1A1 | |
| SCHEMBL379648 | 0.77 | POLB (0.79) | CHRM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28131464 | 0.76 | POLB (0.77) | CHRM1ALDH1A1 | |
| Fluoride SCHEMBL28138824 | 0.76 | POLB (0.77) | CHRM1ALDH1A1 | |
| Bicarbonate SCHEMBL28245554 | 0.76 | POLB (0.59) | CHRM1ALDH1A1 | |
| SCHEMBL9422768 | 0.76 | KDM4E (0.67) | APEX1KDM4EGLAAGTR1AGTR2 | |
| SCHEMBL18955291 | 0.75 | APEX1 (0.73) | APEX1KDM4EPTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |