Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.66 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.66 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531115 | 0.88 | APEX1 (0.65) | APEX1KDM4EGLAAGTR1AGTR2 | |
| SCHEMBL9422768 | 0.86 | KDM4E (0.67) | APEX1KDM4EGLAAGTR1AGTR2 | |
| SCHEMBL18955291 | 0.85 | APEX1 (0.73) | APEX1KDM4EPTGDR2TSHR | |
| SCHEMBL31596375 | 0.85 | APEX1 (0.73) | APEX1KDM4EPTGDR2TSHR | |
| SCHEMBL668252 | 0.83 | LMNA (0.66) | APEX1KDM4EAGTR1AGTR2GAA | |
| Hydrochloric Acid SCHEMBL29205455 | 0.82 | APEX1 (0.76) | APEX1KDM4EPTGDR2TSHR | |
| Hydrochloric Acid SCHEMBL30881912 | 0.82 | APEX1 (0.76) | APEX1KDM4EPTGDR2TSHR | |
| SCHEMBL9136736 | 0.81 | AGTR1 (0.65) | APEX1KDM4EAGTR1AGTR2 | |
| SCHEMBL9137942 | 0.81 | AGTR1 (0.65) | APEX1KDM4EAGTR1AGTR2 | |
| SCHEMBL31485758 | 0.81 | GAA (0.68) | KDM4EGLATSHRGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294631-A | Substituted benzimidazoles useful as angiotension II receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991016313-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-31 | — | — | WO | disclosed |