Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | SLC33A1 | O00400 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705372 | 0.95 | AGTR1 (0.48) | AGTR1AGTR2LTB4R2PPARG | |
| SCHEMBL9530841 | 0.90 | AGTR1 (0.44) | AGTR1AGTR2LTB4R2SLC33A1 | |
| SCHEMBL9531392 | 0.88 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9531666 | 0.87 | AGTR1 (0.48) | AGTR1AGTR2LTB4R2PPARG | |
| SCHEMBL9705092 | 0.86 | AGTR1 (0.47) | AGTR1AGTR2LTB4R2PPARG | |
| SCHEMBL9530681 | 0.86 | AGTR1 (0.47) | AGTR1AGTR2LTB4R2PPARG | |
| SCHEMBL9530734 | 0.84 | AGTR1 (0.47) | AGTR1AGTR2PPARG | |
| SCHEMBL9535036 | 0.81 | AGTR1 (0.37) | AGTR1AGTR2SLC33A1 | |
| SCHEMBL9530850 | 0.81 | AGTR1 (0.35) | AGTR1AGTR2SLC33A1 | |
| SCHEMBL7397017 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |