Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.68 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.68 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10491428 | 0.98 | HTR2A (0.66) | HTR2ATRPM8GPR84SLC6A4MTNR1A | |
| SCHEMBL4510688 | 0.83 | GPR84 (0.63) | HTR2ATRPM8GPR84SLC6A4MTNR1A | |
| SCHEMBL9527828 | 0.81 | HTR2A (0.70) | HTR2ATRPM8GPR84SLC6A4MTNR1A | |
| SCHEMBL12464834 | 0.81 | HTR2A (0.71) | HTR2ATRPM8GPR84SLC6A4MTNR1A | |
| SCHEMBL30724496 | 0.81 | HTR2A (1.00) | HTR2ATRPM8GPR84SLC6A4HSD17B10 | |
| SCHEMBL626030 | 0.81 | HTR2A (1.00) | HTR2ATRPM8GPR84SLC6A4HSD17B10 | |
| Methane SCHEMBL26617454 | 0.80 | HTR2A (0.97) | HTR2ATRPM8GPR84SLC6A4HSD17B10 | |
| SCHEMBL12396967 | 0.80 | GPR84 (0.67) | HTR2ATRPM8GPR84SLC6A4MTNR1A | |
| Hydrochloric Acid SCHEMBL892839 | 0.80 | HTR2A (0.97) | HTR2ATRPM8GPR84SLC6A4HTR1D | |
| Hydrochloric Acid SCHEMBL686594 | 0.80 | HTR2A (0.97) | HTR2ATRPM8GPR84SLC6A4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |