⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040558 | 0.72 | — | — | |
| SCHEMBL21481153 | 0.55 | NFKB1 (0.32) | — | |
| SCHEMBL29375766 | 0.54 | MAPT (0.53) | — | |
| SCHEMBL29418986 | 0.54 | MAPT (0.53) | — | |
| SCHEMBL29398195 | 0.54 | — | — | |
| SCHEMBL3767165 | 0.54 | MAPT (0.53) | — | |
| SCHEMBL33554 | 0.54 | — | — | |
| Water SCHEMBL9798116 | 0.51 | MAPT (0.50) | — | |
| SCHEMBL8984812 | 0.51 | — | — | |
| Water SCHEMBL10406928 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288196-B1 | Sulfonyldecahydro-8H-isoquino[2,1-g][1,6]naphthyridines, optical isomers thereof and related compounds | SYNTEX (U.S.A.) INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5229387-A | Cardiovascular disorders, alpha2-adenoreceptor antagonist or hydroxytryptamine receivers as hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0524004-A1 | Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo[2,3-e]quinolizine derivatives | SYNTEX (U.S.A.) INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4956365-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS, ANTICOAGULANTS, ANTIDIABETIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1990-09-11 | — | — | US | disclosed |
| US-4886798-A | Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers | SYNTEX (U.S.A.) INC. (US) | 1989-12-12 | — | — | US | disclosed |