Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | CETP | P11597 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183707 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL4139016 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL7629650 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL7634493 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL7636178 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL5840193 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL1042215 | 0.94 | SOAT1 (0.68) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL7820705 | 0.91 | CYP2C9 (0.71) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL2968441 | 0.90 | KMT2A (0.66) | CYP2C9HPGDKDM4ENPC1RAB9A | |
| SCHEMBL24420606 | 0.87 | CETP (0.63) | CYP2C9HPGDKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991016313-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-31 | — | — | WO | disclosed |
| EP-0425921-A1 | Benzimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-05-08 | — | — | EP | disclosed |