Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532267 | 0.90 | TSHR (0.54) | TSHRCYP3A4ALOX15CYP2C19TAAR1 | |
| SCHEMBL29555309 | 0.80 | TSHR (0.60) | TSHRTAAR1MAOBMAOAIDO1 | |
| SCHEMBL8548090 | 0.78 | MAOB (0.38) | MAOBMAOA | |
| SCHEMBL20522561 | 0.75 | MAOB (0.44) | TSHRCYP3A4ALOX15CYP2C19MAOB | |
| Oxirane SCHEMBL3317346 | 0.73 | TSHR (0.75) | TSHRTAAR1MAOBMAOAIDO1 | |
| Cyclohexane SCHEMBL8149682 | 0.73 | TSHR (0.83) | TSHRLTA4HIDO1LMNACA1 | |
| Fluoride SCHEMBL27427280 | 0.73 | TSHR (0.94) | TSHRCYP2C19IDO1LMNACA1 | |
| Tetrahydrofuran SCHEMBL28823233 | 0.72 | TSHR (0.65) | TSHRALOX15TAAR1LTA4HIDO1 | |
| SCHEMBL8701180 | 0.72 | TSHR (0.65) | TSHRTAAR1MAOBMAOALTA4H | |
| Dioxane SCHEMBL8701185 | 0.72 | TSHR (0.71) | TSHRALOX15TAAR1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251827-B1 | NEW CYCLIC ETHER DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-09-15 | — | — | EP | disclosed |
| US-4891363-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY LIMITED (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0210804-B1 | PHOSPHATE ESTER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANKYO COMPANY LIMITED (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4794183-A | ANTICANCER AGENTS | SANKYO COMPANY LIMITED (JP) | 1988-12-27 | — | — | US | disclosed |
| EP-0188384-B1 | PHOSPHATE ESTER DERIVATIVES, AND THEIR USE AS ANTI-CANCER AGENTS | SANKYO COMPANY LIMITED (JP) | 1988-11-17 | — | — | EP | disclosed |
| EP-0251827-A2 | New cyclic ether derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-01-07 | — | — | EP | disclosed |
| EP-0210804-A1 | Phosphate ester derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1987-02-04 | — | — | EP | disclosed |
| EP-0188384-A1 | Phosphate ester derivatives, and their use as anti-cancer agents | SANKYO COMPANY LIMITED (JP) | 1986-07-23 | — | — | EP | disclosed |