SCHEMBL9532267

SCHEMBL9532267

C1=C(COCc2ccccc2)OCC1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.54
TAAR1 Q96RJ0 1/20 0.39
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
CYP2C19 P33261 1/20 0.38
IDO1 P14902 1/20 0.36
DAO P14920 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.35
ALOX15 P16050 1/20 0.35
AGXT P21549 1/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA7 P43166 2/20 0.35
CA9 Q16790 2/20 0.35
KDM4E B2RXH2 1/20 0.35
POLB P06746 1/20 0.35
TACR1 P25103 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9533130 0.90 TSHR (0.50) TSHRTAAR1MAOBMAOACYP2C19
SCHEMBL29555309 0.83 TSHR (0.60) TSHRTAAR1MAOBMAOAIDO1
SCHEMBL3394136 0.77 CALM1 (0.44) TSHRTAAR1MAOBMAOACYP2C19
Oxirane SCHEMBL3317346 0.76 TSHR (0.75) TSHRTAAR1MAOBMAOAIDO1
Fluoride SCHEMBL27427280 0.76 TSHR (0.94) TSHRCYP2C19IDO1LMNAAGXT
Dioxane SCHEMBL8701185 0.74 TSHR (0.71) TSHRTAAR1MAOBMAOAIDO1
Fluoride SCHEMBL11189438 0.73 TSHR (0.88) TSHRCYP2C19IDO1LMNAAGXT
SCHEMBL27380 0.73 TSHR (1.00) TSHRCYP2C19IDO1LMNAAGXT
SCHEMBL5311581 0.73 TSHR (1.00) TSHRCYP2C19IDO1LMNAAGXT
Benzene SCHEMBL27997624 0.73 TSHR (1.00) TSHRCYP2C19IDO1LMNAAGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0561941-A1 N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS. SEARLE & CO (US) 1993-09-29 EP disclosed
EP-0251827-B1 NEW CYCLIC ETHER DERIVATIVES, THEIR PREPARATION AND THEIR USE Sankyo Company Limited (JP) 1993-09-15 EP disclosed
US-4891363-A PLATELET ACTIVATING FACTOR ANTAGONISTS SANKYO COMPANY LIMITED (JP) 1990-01-02 US disclosed
EP-0210804-B1 PHOSPHATE ESTER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANKYO COMPANY LIMITED (JP) 1989-05-10 EP disclosed
EP-0251827-A2 New cyclic ether derivatives, their preparation and their use Sankyo Company Limited (JP) 1988-01-07 EP disclosed
EP-0210804-A1 Phosphate ester derivatives, their preparation and their therapeutic use SANKYO COMPANY LIMITED (JP) 1987-02-04 EP disclosed
US-RE30574-E PREEMERGENT AND POSTEMERGENT SHELL OIL COMPANY (US) 1981-04-14 US disclosed