Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330217 | 0.84 | PRCP (0.62) | PRCPSLC22A1HTR2AHRH1OPRM1 | |
| SCHEMBL11662867 | 0.83 | PRCP (0.55) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL27985631 | 0.83 | PRCP (0.60) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL1009943 | 0.82 | PRCP (0.64) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL6429588 | 0.81 | PRCP (0.59) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| Ammonia Solution, Strong SCHEMBL28831335 | 0.80 | PRCP (0.57) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL4340398 | 0.79 | PRCP (0.58) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL5898800 | 0.79 | PRCP (0.61) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL4340396 | 0.79 | PRCP (0.61) | PRCPSLC22A1OPRM1ALDH1A1GAA | |
| SCHEMBL29768301 | 0.78 | PRCP (0.68) | PRCPSLC22A1OPRM1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |
| US-4806547-A | Isoquinoline derivatives, analgesic compounds thereof and method of treating pain | DR. LO. ZAMBELETTI SPA (IT) | 1989-02-21 | — | — | US | disclosed |