Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL11502488 | 0.97 | CA4 (0.59) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL11134436 | 0.95 | CA4 (0.61) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL27658443 | 0.94 | CA4 (0.62) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL516358 | 0.94 | CA4 (0.67) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL27637558 | 0.94 | CA4 (0.62) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL27637566 | 0.94 | CA4 (0.62) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL714315 | 0.92 | CA4 (0.59) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL11599876 | 0.92 | CA4 (0.64) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL714314 | 0.92 | CA4 (0.59) | CA4SMN1; SMN2SLC22A6GABRR1LMNA | |
| Malic Acid SCHEMBL27317233 | 0.92 | CA4 (0.59) | CA4SMN1; SMN2SLC22A6GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2026-01-15 | — | — | US | claimed |
| WO-2025264733-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2025-12-26 | — | — | WO | claimed |
| WO-2024216362-A1 | FLAVOR MODULATION WITH MALATE SALTS AND FOOD-SAFE ACIDS | BARTEK INGREDIENTS, INC. (CA) | 2024-10-24 | — | — | WO | claimed |
| US-20240315956-A1 | METHOD OF PRODUCTION OF THE COMPOSITION OF CYCLOOXYGENASE-2 (COX-2) INHIBITORS | US Nano Food & Drug INC | 2024-09-26 | — | — | US | claimed |
| CN-118064905-A | Electrolyte modification and electrolyte for prolonging service life of alkaline electrolyzed seawater electrode and application | 中国科学院大连化学物理研究所 | 2024-05-24 | — | — | CN | claimed |
| EP-4366732-A1 | METHOD OF PRODUCTION OF THE COMPOSITION OF CYCLOOXYGENASE-2 (COX-2) INHIBITORS | US Nano Food & Drug Inc (US) | 2024-05-15 | — | — | EP | claimed |
| EP-4355107-A1 | MALATE SALTS AS PH-STABILIZING AGENTS FOR HIGH-METHOXYL PECTIN-BASED GUMMY COMPOSITIONS | Bartek Ingredients Inc (CA) | 2024-04-24 | — | — | EP | claimed |
| CN-117813089-A | Process for producing cyclooxygenase-2 (COX-2) inhibitor composition | 美国纳米食品药品公司 | 2024-04-02 | — | — | CN | claimed |
| WO-2023191907-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | FRS GROUP, LLC (US) | 2023-10-05 | — | — | WO | claimed |
| US-20230248033-A1 | FLAVOR MODULATION WITH MALATE SALTS AND FOOD-SAFE ACIDS | BARTEK INGREDIENTS, INC. (CA) | 2023-08-10 | — | — | US | claimed |
| CN-101195759-B | Technique for producing Chinese tallow tree stillingia oil biological diesel oil with solid base catalyst catalysis | UNIV GUIZHOU | 2011-07-20 | — | — | CN | claimed |
| CN-101480387-A | Aceclofenac pharmaceutical composition | WENJU WANG (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-101410021-A | Partially neutralized polycarboxylic acids for acid-sanding | PURAC BIOCHEM BV (NL) | 2009-04-15 | — | — | CN | claimed |
| US-20080260948-A1 | INK AND INK JET RECORDING METHOD | CANON KABUSHIKI KAISHA (JP) | 2008-10-23 | — | — | US | claimed |
| CN-101195759-A | Technique for producing Chinese tallow tree stillingia oil biological diesel oil with solid base catalyst katalysis | UNIV GUIZHOU (CN) | 2008-06-11 | — | — | CN | claimed |
| CN-100390251-C | Preparation of curcas biological diesel oil by solid phase catalytic method | UNIV GUIZHOU (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-1824735-A | Preparation of curcas biological diesel oil by solid phase catalytic method | UNIV GUIZHOU (CN) | 2006-08-30 | — | — | CN | claimed |
| CN-1777415-A | Medicinal composition containing edible acid or its acid salt and its use | XIAO XINGREN (CN) | 2006-05-24 | — | — | CN | claimed |
| US-20020061563-A1 | APPARATUS AND METHOD FOR REMOVING INTERFERING SUBSTANCES FROM A URINE SAMPLE USING AN OXIDIZING AGENT | SPECTRUM LABORATORIES | 2002-05-23 | — | — | US | claimed |
| US-4124636-A | CRYSTALLIZATION FROM AQUEOUS SOLUTION OF L-MALIC ACID AND POTASSIUM ION | TANABE SEIYAKU CO., LTD. (JP) | 1978-11-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | SLC6A12, SLC11A2, KCNN1 | CA4 443/4885SMN1; SMN2 2997/4885SLC22A6 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.