Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365583 | 0.87 | FOLH1 (0.76) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL70392 | 0.87 | FOLH1 (0.76) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL10716112 | 0.85 | FOLH1 (0.68) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL11244449 | 0.85 | FOLH1 (0.58) | FOLH1ALDH1A1ALOX15TSHRSLC16A3 | |
| SCHEMBL31474045 | 0.83 | FOLH1 (0.70) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| Ethylene SCHEMBL18893737 | 0.83 | FOLH1 (0.70) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL729909 | 0.83 | FOLH1 (0.70) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL1615443 | 0.83 | FOLH1 (0.59) | FOLH1ALDH1A1ALOX15TSHRHMGB1 | |
| SCHEMBL15788224 | 0.82 | ALDH1A1 (0.47) | FOLH1ALDH1A1ALOX15TSHRHPGD | |
| SCHEMBL77642 | 0.81 | FOLH1 (0.68) | FOLH1ALDH1A1ALOX15TSHRHMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9090601-B2 | Thiazole derivatives | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20110003807-A1 | Thiazole derivatives | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003806-A1 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| CN-1231666-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1999-10-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003807-A1 | Thiazole derivatives | MTOR, RICTOR, AKT2 | FOLH1 2925/4885ALDH1A1 1687/4885ALOX15 4056/4885 |
| US-20110003806-A1 | Heteroaryls and uses thereof | RICTOR, MTOR, AKT1S1 | FOLH1 4451/4885ALDH1A1 728/4885ALOX15 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.