Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563265 | 0.94 | CHRM2 (0.51) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9353458 | 0.84 | HRH1 (0.48) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| SCHEMBL6616012 | 0.83 | SLC6A3 (0.44) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| SCHEMBL4190405 | 0.79 | DRD3 (0.55) | SLC6A2SLC6A3CYP2D6DRD3MEN1 | |
| SCHEMBL6982214 | 0.79 | SLC6A3 (0.55) | SLC6A2SLC6A3CHRM2ADRA2ACYP2D6 | |
| SCHEMBL1802062 | 0.79 | DRD3 (0.59) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11199043 | 0.78 | SLC6A2 (0.56) | SLC6A2SLC6A3CHRM2ADRA2ACYP2D6 | |
| SCHEMBL9352969 | 0.78 | DRD3 (0.54) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL2476701 | 0.77 | MAPK1 (0.60) | SLC6A2SLC6A3CHRM2HTR1AADRA2A | |
| SCHEMBL942628 | 0.77 | HRH1 (0.66) | TDP1KDM1AMAOAMAOBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335586-B1 | PIPERIDINE & PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UBE INDUSTRIES, LTD. (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4929618-A | ANTIALLERGENS, ANTIHISTAMINES | UBE INDUSTRIES, LTD. (JP) | 1990-05-29 | — | — | US | disclosed |
| EP-0335586-A1 | Piperidine & piperazine derivatives, process for preparing the same and pharmaceutical compositions containing the same | UBE INDUSTRIES, LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |