Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535703 | 0.60 | PLK1 (0.61) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9533873 | 0.59 | PLK1 (0.54) | PLK1CSNK2A1PLK3 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.58 | PLK1 (0.59) | PLK1CSNK2A1PLK3 | |
| Hydrochloric Acid SCHEMBL9221777 | 0.56 | PLK1 (0.49) | PLK1CSNK2A1PLK3 | |
| SCHEMBL22216147 | 0.56 | PLK1 (0.50) | PLK1CSNK2A1PLK3 | |
| SCHEMBL22980483 | 0.53 | PLK1 (0.79) | PLK1CSNK2A1PLK3 | |
| SCHEMBL21678222 | 0.53 | PLK1 (0.54) | PLK1CSNK2A1PLK3 | |
| SCHEMBL21678223 | 0.53 | PLK1 (0.46) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9221790 | 0.52 | CCNA2 (0.47) | — | |
| SCHEMBL22349291 | 0.51 | PLK1 (0.62) | PLK1CSNK2A1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0276835-A1 | Pyrazolothiopyranopyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |