Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9534437 | 0.97 | PLK1 (0.59) | PLK1CSNK2A1PLK3HIF1ACYP11B2 | |
| SCHEMBL22980483 | 0.84 | PLK1 (0.79) | PLK1CSNK2A1PLK3HIF1ACYP11B2 | |
| SCHEMBL9538373 | 0.82 | PLK1 (0.46) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9211095 | 0.81 | PLK1 (0.49) | PLK1CSNK2A1PLK3HIF1ACYP11B2 | |
| Hydrochloric Acid SCHEMBL9216167 | 0.80 | PLK1 (0.47) | PLK1CSNK2A1PLK3HIF1ACYP11B2 | |
| SCHEMBL21678223 | 0.78 | PLK1 (0.46) | PLK1CSNK2A1PLK3KDRTEK | |
| SCHEMBL21024008 | 0.77 | PLK1 (0.45) | PLK1CSNK2A1PLK3CYP11B2ALDH1A1 | |
| SCHEMBL22349291 | 0.77 | PLK1 (0.62) | PLK1CSNK2A1PLK3HIF1ADRD2 | |
| SCHEMBL3142557 | 0.77 | PLK1 (0.93) | PLK1CSNK2A1PLK3HIF1ACYP11B2 | |
| SCHEMBL9211138 | 0.75 | PLK1 (0.44) | PLK1CSNK2A1PLK3HIF1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276834-B1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | claimed |
| US-4734429-A | Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | claimed |