Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477847 | 0.82 | TSHR (0.56) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL11852580 | 0.79 | TSHR (0.54) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL11846561 | 0.79 | TSHR (0.54) | TSHRDNMT1RAD52UHRF1ALDH1A1 | |
| SCHEMBL2494160 | 0.78 | TSHR (0.67) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL9533704 | 0.76 | TSHR (0.51) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL11850067 | 0.75 | TSHR (0.53) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL9532198 | 0.75 | TSHR (0.53) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL11849995 | 0.75 | TSHR (0.50) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL11842534 | 0.75 | TSHR (0.50) | TSHRDNMT1RAD52UHRF1LMNA | |
| SCHEMBL10983242 | 0.75 | TSHR (0.47) | TSHRDNMT1RAD52UHRF1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360261-B1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMA (US) | 1993-10-27 | — | — | EP | claimed |
| US-4871732-A | Substituted imidazo(2,1-b)quinazolin-5(3H)-ones and related tricyclic compounds and use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-03 | — | — | US | claimed |
| EP-0360261-B1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMA (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0360261-A1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4871732-A | Substituted imidazo(2,1-b)quinazolin-5(3H)-ones and related tricyclic compounds and use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-03 | — | — | US | disclosed |