Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | SLC33A1 | O00400 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535678 | 0.93 | AGTR1 (0.44) | AGTR1AGTR2SLC33A1 | |
| SCHEMBL9530314 | 0.93 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL9534844 | 0.91 | AGTR1 (0.38) | AGTR1AGTR2ADORA3 | |
| SCHEMBL9534180 | 0.91 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9554005 | 0.91 | AGTR1 (0.40) | AGTR1AGTR2ADORA3SLC33A1 | |
| SCHEMBL9555091 | 0.90 | AGTR1 (0.40) | AGTR1AGTR2ADORA3SLC33A1 | |
| SCHEMBL9554102 | 0.90 | AGTR1 (0.40) | AGTR1AGTR2ADORA3SLC33A1 | |
| SCHEMBL9531764 | 0.90 | AGTR1 (0.40) | AGTR1AGTR2ADORA3 | |
| SCHEMBL9531587 | 0.89 | AGTR1 (0.42) | AGTR1AGTR2ADORA3 | |
| SCHEMBL9035984 | 0.89 | AGTR1 (0.38) | AGTR1AGTR2SLC33A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238952-A | Treating glaucoma disorders | G. D. SEARLE & CO. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |
| US-5087634-A | N-substituted imidazol-2-one compounds for treatment of circulatory disorders | G. D. SEARLE & CO. (US) | 1992-02-11 | — | — | US | disclosed |