Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537285 | 0.89 | MAPK8 (0.56) | MAPTLMNAHPGDPKMALOX15 | |
| SCHEMBL11038273 | 0.88 | EDNRA (0.57) | MAPTLMNASMN1; SMN2HTTEDNRA | |
| SCHEMBL9539511 | 0.84 | KDM4E (0.58) | MAPTMAPK1SMN1; SMN2HPGDHTT | |
| SCHEMBL15004854 | 0.82 | MAPK1 (0.58) | MAPTLMNAMAPK1SMN1; SMN2HPGD | |
| SCHEMBL9535567 | 0.81 | PPARG (0.48) | MAPTLMNAMAPK1SMN1; SMN2HPGD | |
| SCHEMBL28079273 | 0.77 | MAPK1 (0.53) | MAPTLMNAMAPK1SMN1; SMN2HPGD | |
| SCHEMBL15452835 | 0.77 | MAPK8 (0.50) | MAPTHPGDPKMALOX15HSD17B10 | |
| SCHEMBL9538497 | 0.76 | MAPK8 (0.55) | MAPTLMNAHPGDPKMALOX15 | |
| SCHEMBL7111400 | 0.76 | EDNRA (0.56) | MAPTLMNASMN1; SMN2HPGDHTT | |
| SCHEMBL29539968 | 0.76 | MAPT (0.62) | MAPTLMNASMN1; SMN2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |