Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536815 | 0.90 | MAPK8 (0.51) | PPARGMAPTHPGDPKMALOX15 | |
| SCHEMBL10758409 | 0.89 | PPARG (0.60) | PPARGMAPTHTTEDNRALMNA | |
| SCHEMBL9534704 | 0.86 | KDM4E (0.53) | PPARGMAPTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL9534703 | 0.81 | MAPT (0.52) | PPARGMAPTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL9538497 | 0.79 | MAPK8 (0.55) | PPARGMAPTHPGDPKMALOX15 | |
| SCHEMBL9535097 | 0.79 | PPARG (0.40) | PPARGMAPTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL10756621 | 0.78 | PPARG (0.53) | PPARGPKMEDNRALMNAPPARA | |
| SCHEMBL9538268 | 0.77 | MAPK8 (0.52) | MAPTHPGDPKMALOX15HSD17B10 | |
| SCHEMBL9144495 | 0.76 | KDM4E (0.58) | PPARGMAPTHPGDHTTEDNRA | |
| SCHEMBL9141602 | 0.74 | KDM4E (0.53) | PPARGMAPTHPGDHTTEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |