Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.79 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.79 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.79 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.79 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.79 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.79 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.79 |
| ▸ | GABRP | O00591 | 9/20 | 0.79 |
| ▸ | GABRD | O14764 | 9/20 | 0.79 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.79 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.79 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.79 |
| ▸ | GABRE | P78334 | 9/20 | 0.79 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.79 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.79 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389616 | 0.93 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10389299 | 0.92 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9536518 | 0.92 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9537306 | 0.92 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9534689 | 0.90 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10390438 | 0.90 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10706549 | 0.89 | GABRA1 (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9536668 | 0.89 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9534998 | 0.89 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9427814 | 0.89 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234173-B1 | PHENOXY-SUBSTITUTED BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | claimed |
| US-4945090-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-07-31 | — | — | US | claimed |
| US-4945090-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-07-31 | — | — | US | disclosed |