Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477010 | 0.81 | TSHR (0.66) | HPGDTSHRRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9326177 | 0.77 | HPGD (0.80) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL9326976 | 0.77 | HPGD (0.80) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL9143110 | 0.76 | MGAM (0.78) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL9143106 | 0.76 | MGAM (0.78) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL8120013 | 0.74 | HPGD (0.60) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL9533083 | 0.74 | FFAR1 (0.63) | HPGDTSHRRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9570687 | 0.74 | PIM1 (0.78) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL9570682 | 0.74 | PIM1 (0.78) | HPGDMAOAMAOBPIM1PIM2 | |
| SCHEMBL8128807 | 0.74 | HPGD (0.61) | HPGDMAOAMAOBPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555251-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | claimed |
| WO-1992007838-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | claimed |