Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 4/20 | 0.31 |
| ▸ | GRM6 | O15303 | 2/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795999 | 1.00 | TDP1 (0.38) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL3779680 | 0.87 | POLB (0.33) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL27218570 | 0.82 | POLB (0.42) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL13170561 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL13170558 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL3137346 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL13170560 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL13170557 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL3791279 | 0.76 | GABRR1 (0.39) | TDP1POLBPKMGRM2GRM4 | |
| SCHEMBL3683146 | 0.76 | POLB (0.43) | TDP1POLBGRM2GRM4GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314098-B1 | IMIDE DERIVATIVES, THEIR PRODUCTION AND USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-08-04 | — | — | EP | disclosed |
| EP-0261688-B1 | IMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-4948799-A | ANTIPSYCHOTIC DRUGS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-08-14 | — | — | US | disclosed |
| US-4937249-A | Neuroleptic agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-06-26 | — | — | US | disclosed |
| US-4812461-A | Imide derivatives and their use in the treatment psychosis | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1989-03-14 | — | — | US | disclosed |