Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | EDNRA | P25101 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537134 | 0.88 | KDM4E (0.58) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9540898 | 0.87 | KDM4E (0.57) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL10761647 | 0.83 | KDM4E (0.64) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL6456184 | 0.82 | KDM4E (0.49) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9146455 | 0.81 | MEN1 (0.58) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9535102 | 0.80 | KDM4E (0.44) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL10759304 | 0.79 | KDM4E (0.59) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL10758715 | 0.79 | KDM4E (0.58) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9144495 | 0.78 | KDM4E (0.58) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9536517 | 0.78 | KDM4E (0.58) | KDM4EEDNRAMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |