Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | EED | O75530 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HLA-A | P04439 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538063 | 0.86 | KCNH2 (1.00) | KCNH2GAAEEDHRH3SIGMAR1 | |
| SCHEMBL9774798 | 0.82 | SSTR5 (0.64) | KCNH2GAAEEDHRH3SIGMAR1 | |
| SCHEMBL9689872 | 0.81 | KCNH2 (0.90) | KCNH2GAAEEDHRH3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9535454 | 0.80 | KCNH2 (0.51) | KCNH2HRH3ABCB1HTR2AHRH1 | |
| SCHEMBL9534992 | 0.78 | CDC7 (0.54) | KCNH2HRH3HRH4 | |
| SCHEMBL8135558 | 0.77 | KCNH2 (0.45) | KCNH2HRH3DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9535340 | 0.77 | CDC7 (0.53) | KCNH2HRH3HRH4 | |
| SCHEMBL9536746 | 0.75 | KCNH2 (0.46) | KCNH2LMNAMAPTDRD2SSTR5 | |
| SCHEMBL9779515 | 0.75 | SSTR5 (0.66) | KCNH2GAAEEDHRH3SIGMAR1 | |
| SCHEMBL20715315 | 0.75 | KCNH2 (0.87) | KCNH2GAAEEDHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | claimed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | claimed |
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |