Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135558 | 0.80 | KCNH2 (0.45) | KCNH2CDC7DBF4ROCK2ROCK1 | |
| SCHEMBL9689110 | 0.79 | KCNH2 (0.57) | KCNH2MAPT | |
| SCHEMBL9534992 | 0.78 | CDC7 (0.54) | KCNH2CDC7DBF4POLBBRD4 | |
| Hydrochloric Acid SCHEMBL9535454 | 0.78 | KCNH2 (0.51) | KCNH2CDC7DBF4 | |
| Hydrochloric Acid SCHEMBL9535340 | 0.77 | CDC7 (0.53) | KCNH2CDC7DBF4POLBBRD4 | |
| SCHEMBL9687566 | 0.77 | KCNH2 (0.42) | KCNH2CDC7DBF4DRD2DRD3 | |
| SCHEMBL9535712 | 0.75 | KCNH2 (0.75) | KCNH2HSD17B10DRD2DRD3SSTR5 | |
| Water SCHEMBL9539482 | 0.75 | KCNH2 (0.46) | KCNH2CDC7DBF4POLB | |
| SCHEMBL9689825 | 0.74 | CDC7 (0.47) | KCNH2CDC7DBF4BRD4ATAD2 | |
| SCHEMBL9697289 | 0.73 | HRH1 (0.43) | KCNH2NAAADRD2DRD3SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |