Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537135 | 1.00 | KDM4E (0.41) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL11022324 | 0.95 | KDM4E (0.42) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9535836 | 0.91 | MEN1 (0.44) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL10760702 | 0.91 | MEN1 (0.43) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL10760718 | 0.91 | MEN1 (0.43) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9536287 | 0.89 | KDM4E (0.47) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9537498 | 0.88 | KDM4E (0.44) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL6438548 | 0.84 | KDM4E (0.43) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9538371 | 0.83 | MAPK8 (0.48) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9538611 | 0.83 | MAPK8 (0.48) | KDM4EMAPTHTTMAPK8EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | claimed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | claimed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | claimed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |