Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538611 | 1.00 | MAPK8 (0.48) | MAPK8KDM4EMAPTHTTPLA2G2A | |
| SCHEMBL10757952 | 0.92 | KDM4E (0.53) | KDM4EMAPTHTTPLA2G2AMEN1 | |
| SCHEMBL10760919 | 0.92 | KDM4E (0.53) | KDM4EMAPTHTTPLA2G2AMEN1 | |
| SCHEMBL9534868 | 0.88 | MEN1 (0.54) | MAPK8KDM4EMAPTHTTMEN1 | |
| SCHEMBL10758715 | 0.85 | KDM4E (0.58) | MAPK8KDM4EMAPTHTTMEN1 | |
| SCHEMBL10652966 | 0.84 | KDM4E (0.51) | MAPK8KDM4EMAPTHTTMEN1 | |
| SCHEMBL9536907 | 0.84 | KDM4E (0.54) | MAPK8KDM4EMAPTHTTPLA2G2A | |
| SCHEMBL9537135 | 0.83 | KDM4E (0.41) | MAPK8KDM4EMAPTHTTPLA2G2A | |
| SCHEMBL9535878 | 0.83 | KDM4E (0.41) | MAPK8KDM4EMAPTHTTPLA2G2A | |
| SCHEMBL27291037 | 0.80 | MAPK8 (0.55) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |