Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805326 | 0.84 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9383372 | 0.79 | AKR1B1 (0.59) | AKR1B1 | |
| SCHEMBL9673557 | 0.79 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL9384403 | 0.77 | AKR1B1 (0.57) | AKR1B1 | |
| SCHEMBL9536275 | 0.77 | GSK3B (0.36) | AKR1B1 | |
| SCHEMBL8465965 | 0.77 | GSK3B (0.36) | AKR1B1 | |
| SCHEMBL9385978 | 0.75 | AKR1B1 (0.55) | AKR1B1 | |
| SCHEMBL5107203 | 0.74 | GSK3B (0.43) | AKR1B1 | |
| SCHEMBL9388594 | 0.73 | AKR1B1 (0.58) | AKR1B1 | |
| SCHEMBL4390579 | 0.70 | AKR1B1 (0.44) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555327-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0553263-A1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006975-A1 | 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992006974-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |