Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384403 | 0.84 | AKR1B1 (0.57) | AKR1B1 | |
| SCHEMBL9536279 | 0.84 | AKR1B1 (0.51) | AKR1B1 | |
| SCHEMBL11979735 | 0.83 | AKR1B1 (0.53) | AKR1B1 | |
| SCHEMBL9383372 | 0.83 | AKR1B1 (0.59) | AKR1B1 | |
| SCHEMBL9385978 | 0.82 | AKR1B1 (0.55) | AKR1B1 | |
| SCHEMBL8804611 | 0.80 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9383374 | 0.80 | AKR1B1 (0.81) | AKR1B1 | |
| SCHEMBL9383306 | 0.80 | AKR1B1 (0.72) | AKR1B1 | |
| SCHEMBL9673557 | 0.80 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL5107203 | 0.76 | GSK3B (0.43) | AKR1B1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | claimed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | claimed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | claimed |
| EP-0519600-B1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PROD (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0519600-A1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5169948-A | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| US-5106978-A | Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |