Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | THPO | P40225 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.56 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536401 | 0.85 | PRMT5 (0.59) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19351868 | 0.85 | PRMT5 (0.60) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17560270 | 0.84 | PRMT5 (0.58) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9538527 | 0.82 | TP53 (0.72) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9535328 | 0.82 | CYP1A2 (0.76) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9536903 | 0.82 | NPY1R (0.84) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9537748 | 0.82 | CYP1A2 (0.76) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL9587965 | 0.81 | CYP1A2 (0.74) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL9589088 | 0.81 | CYP1A2 (0.74) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9588852 | 0.81 | CYP3A4 (0.62) | TP53CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |