Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574215 | 1.00 | AKR1B1 (0.51) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| Hydrochloric Acid SCHEMBL10572120 | 0.99 | AKR1B1 (0.50) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL10571394 | 0.86 | AKR1B1 (0.51) | AKR1B1AKR1B10MAPTAKR1A1APP | |
| SCHEMBL10570941 | 0.84 | RARA (0.39) | AKR1B1MAPTRARARARBRARG | |
| SCHEMBL10651444 | 0.83 | AKR1B1 (0.59) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL10754110 | 0.83 | AKR1B1 (0.56) | AKR1B1AKR1B10MAPTAKR1A1KIF11 | |
| SCHEMBL10569394 | 0.83 | AKR1B1 (0.59) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL10919189 | 0.83 | AKR1B1 (0.59) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL10649371 | 0.83 | AKR1B1 (0.56) | AKR1B1AKR1B10MAPTAKR1A1KIF11 | |
| SCHEMBL7177095 | 0.83 | AKR1B1 (0.55) | AKR1B1AKR1B10MAPTAKR1A1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352959-B1 | RESOLUTION PROCESS FOR RACEMIC SPIRO-HYDANTOINS | PFIZER INC. (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5206367-A | Preparation of optically active spiro-hydantoins | PFIZER INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5006657-A | Intermediates in a resolution process for racemic spiro hydantoins | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4952694-A | Novel resolution process for racemic spiro-hydantoins | PFIZER INC. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0352959-A1 | Resolution process for racemic spiro-hydantoins | PFIZER INC. (US) | 1990-01-31 | — | — | EP | disclosed |
| US-4841079-A | Process for the production of asymmetric hydantoins | PFIZER, INC. (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0173522-B1 | PROCESS AND INTERMEDIATES FOR SORBINIL | PFIZER INC. (US) | 1988-12-07 | — | — | EP | disclosed |
| EP-0172719-B1 | PROCESS FOR THE PRODUCTION AS ASYMMETRIC HYDANTOINS | PFIZER INC. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4716113-A | Process for the production of an (S)-methyl or (S)-ethyl 4-amino-6-fluorochroman-4-carboxylate | PFIZER INC. (US) | 1987-12-29 | — | — | US | disclosed |
| US-4704461-A | Processes and intermediates for sorbinil | PFIZER INC. (US) | 1987-11-03 | — | — | US | disclosed |
| CN-85105869-A | The preparation method of asymmetric glycolylurea | — | 1987-01-28 | — | — | CN | disclosed |
| US-4620019-A | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil | PFIZER INC. (US) | 1986-10-28 | — | — | US | disclosed |
| EP-0173522-A2 | Process and intermediates for sorbinil | PFIZER INC. (US) | 1986-03-05 | — | — | EP | disclosed |
| EP-0172719-A1 | Process for the production as asymmetric hydantoins | PFIZER INC. (US) | 1986-02-26 | — | — | EP | disclosed |