SCHEMBL9536738

SCHEMBL9536738

Fc1ccc(Cn2c(CC3CCN(CCn4c(S)nc5cncnc54)CC3)nc3ccccc32)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.44
USP2 O75604 5/20 0.44
CYP3A4 P08684 5/20 0.44
CYP2D6 P10635 4/20 0.44
CYP2C9 P11712 4/20 0.44
CYP2C19 P33261 3/20 0.44
HIF1A Q16665 2/20 0.44
SSTR5 P35346 2/20 0.44
RAB9A P51151 1/20 0.43
ALDH1A1 P00352 2/20 0.43
MAPK1 P28482 2/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
HBB P68871 1/20 0.43
KCNH2 Q12809 3/20 0.43
HRH1 P35367 3/20 0.43
CHRM1 P11229 2/20 0.43
NR4A2 P43354 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10548374 0.92 KCNH2 (0.47) CYP1A2USP2CYP3A4CYP2D6CYP2C9
SCHEMBL10549816 0.88 SSTR5 (0.44) CYP1A2USP2CYP3A4CYP2D6CYP2C9
SCHEMBL9564956 0.82 CYP1A2 (0.54) CYP1A2USP2CYP3A4CYP2D6CYP2C9
SCHEMBL10547736 0.81 KCNH2 (0.46) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9536935 0.80 NPSR1 (0.55) CYP2D6SSTR5RAB9AKCNH2HRH1
SCHEMBL9536663 0.79 RAB9A (0.55) CYP1A2USP2CYP3A4CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL9537670 0.79 RAB9A (0.55) CYP1A2USP2CYP3A4CYP2D6CYP2C19
SCHEMBL9537554 0.79 HRH1 (0.63) CYP1A2USP2CYP3A4CYP2D6CYP2C19
SCHEMBL9564883 0.79 CYP1A2 (0.45) CYP1A2USP2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL9539517 0.78 HRH1 (0.62) CYP1A2USP2CYP3A4CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0151826-B1 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines JANSSEN PHARMACEUTICA N.V. (BE) 1993-03-31 EP claimed
EP-0151826-B1 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines JANSSEN PHARMACEUTICA N.V. (BE) 1993-03-31 EP disclosed
US-4839374-A TREATING ALLERGIES JANSSEN PHARMACEUTICA, N.V. (BE) 1989-06-13 US disclosed
US-4695575-A ANTIHISTAMINES JANSSEN PHARMACEUTICA, N.V. (BE) 1987-09-22 US disclosed
EP-0151826-A1 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines JANSSEN PHARMACEUTICA N.V. (BE) 1985-08-21 EP disclosed
US-4482484-A Compounds and hapten-immunoglobulin conjugates derived from them LILLY INDUSTRIES LIMITED (GB) 1984-11-13 US disclosed
EP-0053915-B1 NOVEL COMPOUNDS AND HAPTEN-IMMUNOGLOBULIN CONJUGATES DERIVED FROM THEM Lilly Industries Limited (GB) 1984-07-04 EP disclosed
US-4442032-A Isothiocyanato-azobenzene-sulfonic, arsonic and substituted-glutamic acid haptens LILLY INDUSTRIES LIMITED (GB) 1984-04-10 US disclosed
EP-0053915-A1 Novel compounds and hapten-immunoglobulin conjugates derived from them Lilly Industries Limited (GB) 1982-06-16 EP disclosed