Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536795 | 1.00 | DHFR (0.45) | DHFR | |
| SCHEMBL9536799 | 1.00 | DHFR (0.45) | DHFR | |
| SCHEMBL9537920 | 0.87 | DHFR (0.58) | DHFR | |
| SCHEMBL9537916 | 0.87 | DHFR (0.58) | DHFR | |
| SCHEMBL9537911 | 0.87 | DHFR (0.58) | DHFR | |
| SCHEMBL10494211 | 0.87 | DHFR (0.39) | DHFR | |
| SCHEMBL10494200 | 0.87 | DHFR (0.39) | DHFR | |
| SCHEMBL10494207 | 0.87 | DHFR (0.39) | DHFR | |
| SCHEMBL10805446 | 0.82 | DHFR (0.60) | DHFR | |
| SCHEMBL10805463 | 0.82 | DHFR (0.60) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026851-A | Antineoplastic agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-25 | — | — | US | claimed |
| EP-0215063-B1 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES | UNIV PRINCETON (US) | 1993-11-03 | — | — | EP | disclosed |
| US-5026851-A | Antineoplastic agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-25 | — | — | US | disclosed |
| US-4684653-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1987-08-04 | — | — | US | disclosed |