Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | CTSV | O60911 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743035 | 0.85 | PLK1 (0.62) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL28252959 | 0.84 | HPGD (0.59) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL27419359 | 0.84 | PLK1 (0.60) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL7417286 | 0.82 | EGLN1 (0.53) | HDAC8MMP3CTSVCTSLCTSB | |
| SCHEMBL2117675 | 0.81 | PLK1 (0.66) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL9312700 | 0.79 | HPGD (0.64) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL18457265 | 0.79 | PLK1 (0.62) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL5561110 | 0.78 | HDAC8 (0.62) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL4721719 | 0.78 | HDAC8 (0.62) | PLK1HDAC8MMP3HPGDHDAC3 | |
| SCHEMBL10611437 | 0.78 | HPGD (0.60) | CTSVCTSLCTSSHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549600-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| WO-1992005163-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1992-04-02 | — | — | WO | disclosed |
| US-4785019-A | ANTIGROWTH AGENTS | CHEVRON RESEARCH COMPANY (US) | 1988-11-15 | — | — | US | disclosed |