Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 5/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536956 | 0.91 | KCNH2 (0.49) | KCNH2SSTR5NR4A2POLBHRH1 | |
| SCHEMBL9536186 | 0.90 | MAPT (0.56) | SSTR5POLBTP53 | |
| SCHEMBL10550102 | 0.89 | GNRHR (0.51) | KCNH2SSTR5NR4A2POLBHRH1 | |
| SCHEMBL10547215 | 0.88 | POLB (0.49) | KCNH2SSTR5NR4A2POLBHRH1 | |
| SCHEMBL10547164 | 0.87 | KCNH2 (0.48) | KCNH2SSTR5NR4A2POLBHRH1 | |
| SCHEMBL9537582 | 0.87 | TP53 (0.53) | POLBTP53 | |
| SCHEMBL10552831 | 0.87 | KCNH2 (0.47) | KCNH2SSTR5NR4A2HRH1TACR2 | |
| Oxalic Acid SCHEMBL10552513 | 0.87 | SSTR5 (0.51) | KCNH2SSTR5NR4A2HRH1TACR2 | |
| SCHEMBL10550052 | 0.86 | POLB (0.47) | KCNH2SSTR5NR4A2POLBHRH1 | |
| SCHEMBL9537249 | 0.86 | SCN9A (0.53) | KCNH2SSTR5NR4A2HRH1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |