Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | EED | O75530 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535641 | 0.90 | SSTR5 (0.52) | HRH1CYP2D6MAPK1SSTR5KCNH2 | |
| SCHEMBL9536631 | 0.85 | SSTR5 (0.48) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9537168 | 0.84 | SSTR5 (0.49) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9537130 | 0.82 | KCNH2 (0.63) | HRH1CYP2D6MAPK1KCNH2NR4A2 | |
| Bromide SCHEMBL10798602 | 0.82 | HRH1 (0.52) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9537554 | 0.80 | HRH1 (0.63) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9697310 | 0.80 | SSTR5 (0.80) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9536075 | 0.80 | HRH1 (0.62) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| Hydrochloric Acid SCHEMBL9539517 | 0.80 | HRH1 (0.62) | HRH1CYP2D6SSTR5KCNH2NR4A2 | |
| SCHEMBL9541656 | 0.79 | HRH1 (0.61) | HRH1CYP2D6SSTR5KCNH2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |