Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536849 | 0.82 | HRH1 (0.62) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9535641 | 0.80 | SSTR5 (0.52) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9536631 | 0.75 | SSTR5 (0.48) | HRH1CYP2D6LMNASMN1; SMN2TACR2 | |
| SCHEMBL9537168 | 0.75 | SSTR5 (0.49) | HRH1CYP2D6LMNASMN1; SMN2TACR2 | |
| SCHEMBL9537373 | 0.75 | TP53 (0.52) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9537130 | 0.73 | KCNH2 (0.63) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9536691 | 0.72 | CYP2D6 (0.56) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10801027 | 0.72 | TP53 (0.49) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9535858 | 0.71 | PKM (0.51) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1151838 | 0.70 | SSTR5 (0.63) | HRH1CYP2D6LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |