Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.63 |
| ▸ | HTR3A | P46098 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537283 | 0.90 | KCNH2 (0.58) | KCNH2HTR3ATP53MEN1LMNA | |
| Water SCHEMBL10550887 | 0.89 | KCNH2 (0.57) | KCNH2HTR3ATP53MEN1LMNA | |
| SCHEMBL9382803 | 0.88 | KCNH2 (0.64) | KCNH2HTR3ACYP2D6HRH1CYP3A4 | |
| SCHEMBL9537539 | 0.88 | HTR3A (0.62) | KCNH2HTR3ATP53LMNAMAPT | |
| SCHEMBL9540054 | 0.86 | TP53 (0.59) | KCNH2HTR3ATP53MEN1LMNA | |
| SCHEMBL9535902 | 0.84 | MEN1 (0.63) | KCNH2TP53MEN1LMNAMAPT | |
| SCHEMBL9535843 | 0.83 | KCNH2 (0.54) | KCNH2TP53LMNAMAPT | |
| SCHEMBL1584245 | 0.83 | KCNH2 (0.63) | KCNH2MEN1LMNAMAPTKMT2A | |
| SCHEMBL9540203 | 0.82 | KCNH2 (0.64) | KCNH2HTR3AHRH1CHRM1NR4A2 | |
| SCHEMBL14173582 | 0.82 | KCNH2 (0.50) | KCNH2HTR3ATP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |