Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.53 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29050926 | 1.00 | KIF11 (0.53) | KIF11MDM4MDM2KCNN4KMT2A | |
| SCHEMBL3184027 | 0.84 | KIF11 (0.51) | KIF11KCNN4KMT2A | |
| SCHEMBL3184012 | 0.84 | KIF11 (0.51) | KIF11KCNN4KMT2A | |
| Bromide SCHEMBL1200794 | 0.83 | KIF11 (0.50) | KIF11KCNN4KMT2A | |
| Bromide SCHEMBL1200791 | 0.83 | KIF11 (0.50) | KIF11KCNN4KMT2A | |
| SCHEMBL29053899 | 0.80 | KIF11 (0.68) | KIF11 | |
| SCHEMBL29053902 | 0.80 | KIF11 (0.68) | KIF11 | |
| SCHEMBL31503681 | 0.78 | KIF11 (0.51) | KIF11KCNN4KMT2A | |
| SCHEMBL12872399 | 0.76 | KIF11 (0.85) | KIF11 | |
| SCHEMBL3439368 | 0.76 | KIF11 (0.85) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535192-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. | HOFFMANN LA ROCHE (CH) | 1993-04-07 | — | — | EP | disclosed |