Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536800 | 0.81 | DDB1 (0.55) | NPY1RLMNAKCNH2 | |
| SCHEMBL9537056 | 0.80 | CCR3 (0.56) | HTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL29232383 | 0.80 | DDB1 (0.54) | NPY1RLMNAKCNH2 | |
| Hydrochloric Acid SCHEMBL30918533 | 0.80 | DDB1 (0.54) | NPY1RLMNAKCNH2 | |
| SCHEMBL6440718 | 0.80 | ESR2 (0.52) | MAPK1LMNAL3MBTL1 | |
| SCHEMBL9537283 | 0.79 | KCNH2 (0.58) | GBA1HTTNPY1RLMNAKCNH2 | |
| SCHEMBL9536325 | 0.79 | KDM4E (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Water SCHEMBL10550887 | 0.78 | KCNH2 (0.57) | GBA1HTTNPY1RLMNAKCNH2 | |
| SCHEMBL7481782 | 0.78 | CHRM4 (0.52) | MAPK1HTTNPY1RCHRM2CHRM4 | |
| Oxalic Acid SCHEMBL10800983 | 0.77 | HDAC6 (0.52) | GBA1NPY1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |